Diosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat
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Abstract:
Background and Objective: Chronic diabetes mellitus (DM) leads to cardiovascular dysfunction. Diosgenin is a natural steroidal saponin with cardiovascular protective potential. In this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats (n = 28) were divided into equal-sized control, diosgenin-treated control, diabetic, and diosgenin-treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg/kg). Diosgenin was administered p.o. at a dose of 40 mg/kg for 7 weeks. Some markers of oxidative stress including malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) were measured in cardiac tissue homogenate. Results: It was found out that diabetic group had an elevated MDA content (p
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diosgenin attenuates cardiac oxidative stress in streptozotocin- induced diabetic rat
background and objective: chronic diabetes mellitus (dm) leads to cardiovascular dysfunction. diosgenin is a natural steroidal saponin with cardiovascular protective potential. in this research study, the beneficial effect of diosgenin was evaluated on some markers of oxidative stress in cardia tissue of streptozotocin (stz)-diabetic rats. materials and methods: male wistar rats (n = 28) were d...
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Journal title
volume 4 issue 1
pages 13- 18
publication date 2016-03-01
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